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    Formulation Process

    LipoNXT Production

    LipoNXT Liposomal Production Process

    At LipoNXT, we’ve developed a cutting-edge, patented process to create highly stable, bioavailable liposomal formulations in powder form. Our innovative production method ensures superior encapsulation efficiency and long-term stability, setting a new standard for liposomal technology. Here’s how we do it:

    1. Preparation of Active Compound Solution

    We begin by preparing a solution of the active compound (e.g., Vitamin C) mixed with gum arabic:

  • Vitamin C is dissolved in water.
  • Gum arabic is added, and the mixture undergoes nano-milling, transforming the gum arabic into protective nanospheres. These nanospheres encapsulate the active ingredient, forming a stable core ready for integration into the liposome.

    • 2. Phospholipid Solution

    Next, we prepare the phospholipid structure:

  • Phospholipids are dissolved in water at 80°C and processed through nano-milling, creating a fine dispersion for optimal liposome formation.

    • 3. In-Situ Combination and Nano-Milling

  • The nanosphere solution (Solution A) is mixed with the phospholipid solution (Solution B).
  • This combined mixture undergoes further nano-milling, ensuring seamless encapsulation of the active compound within the phospholipid bilayer.

    • 4. High-Pressure Homogenization

    The mixed formulation is then subjected to high-pressure homogenization, a crucial step that refines the liposomes, ensuring uniform size and shape. This process is repeated three times for maximum stability and consistency.

    5. Spray Drying for Stabilized Liposomes

    Finally, the liposomal formulation is transformed into a dry powder through a precise spray drying process:

  • Water is evaporated without disrupting the liposome’s core, thanks to the protective nanosphere arrangement.
  • This results in a dry, unilamellar liposomal powder that is uniform in size, highly stable, and offers exceptional bioavailability.

    • The LipoNXT Advantage

    Our proprietary process creates liposomal powders that deliver:

    • High stability and long shelf life
    • Uniform particle size with narrow distribution
    • High bioavailability for effective absorption
    • Superior encapsulation efficiency, ensuring optimal delivery of active ingredients

      • LipoNXT’s innovative liposome technology is ideal for a range of applications, including surface modifications and ligand-targeted liposomal products. Discover the future of bioactive delivery with LipoNXT.
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